Morphometric effect of nandrolone decanoate used as doping in sport on femur of rats in puberty period

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Details: Category: 2010, Volume 6; 31 December 2010; Hits: 64

Sefa Lök¹, Hakan Yalcin²

¹Physical Education and Sports Academy, Konya, Konya, Turkey
²Department of Anatomy, Veterinary Faculty, Selcuk University, Konya, Konya, Turkey

Author for correspondence: Sefa Lök; Physical Education and Sports Academy, Konya, Konya, Turkey; email: This email address is being protected from spambots. You need JavaScript enabled to view it.

Abstract

Background and Study Aim: The aim of this research is to show the morphometric effect of nandrolone that is used as doping in sport on femur of rats in puberty period.

Material and Methods: A total of 60 Sprague–Dawley rats (30 days old) were divided into three equal groups. The control group (male n=10, female n=10) was nourished for 4 weeks without any substance being administered. For the peanut oil group (male n=10, female n=10), peanut oil was used as diluent of nandrolone decanoate (500 mcl). It was administered for 5 days via intraperitoneal injection, with a pause of 2 days and the same application was done for 4 weeks.. Nandrolone decanoate was applied for 5 days to the Nandrolone group (male n=10, female n=10) in 10 mg/kg dose by being diluted in 500 mcl peanut oil via intraperitoneal injection and the same was applied for 4 weeks having taken a 2-day long pause. Rats were euthanatized at the end of fourth week. Back extremity bones of materials were revealed by being dissected and put to maceration operation.

Results: Morphometric measures were taken by determining the anatomic reference points (length, corpus, cortex-cortical bone thickness-substantiate compact, medullar wide-cavity medullar) that would be measured of femur bones that are on right side. It was determined that nandrolone caused shortening in femur length (p<0.05) in male and female rats when compared to peanut oil and control groups.
Conclusions: Nandrolone may delay the bone formation in the puberty period.

Key words: femur, morphometric, nandrolone

AMA:
Lök S, Yalcin H. Morphometric effect of nandrolone decanoate used as doping in sport on femur of rats in puberty period. ARCH BUDO. 2010;6(4)
APA:
Lök, S., & Yalcin, H. (2010). Morphometric effect of nandrolone decanoate used as doping in sport on femur of rats in puberty period. ARCH BUDO, 6(4)
Chicago:
Lök, Sefa, Yalcin Hakan. 2010. "Morphometric effect of nandrolone decanoate used as doping in sport on femur of rats in puberty period". ARCH BUDO 6 (4)
Harvard:
Lök, S., and Yalcin, H. (2010). Morphometric effect of nandrolone decanoate used as doping in sport on femur of rats in puberty period. ARCH BUDO, 6(4)
MLA:
Lök, S., and Yalcin, H. "Morphometric effect of nandrolone decanoate used as doping in sport on femur of rats in puberty period." ARCH BUDO, vol. 6, no. 4, 2010
Vancouver:
Lök S, Yalcin H. Morphometric effect of nandrolone decanoate used as doping in sport on femur of rats in puberty period. ARCH BUDO 2010; 6(4)

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